Combination of Paeoniae Radix and Cnidii Rhizoma Prolonged Survival of Fully Mismatched Cardiac Allografts and Generated Regulatory Cells in Mice
Identifieur interne : 000414 ( Main/Exploration ); précédent : 000413; suivant : 000415Combination of Paeoniae Radix and Cnidii Rhizoma Prolonged Survival of Fully Mismatched Cardiac Allografts and Generated Regulatory Cells in Mice
Auteurs : Xiangyuan Jin [Japon, République populaire de Chine] ; Lei Yu [Japon, République populaire de Chine] ; Masateru Uchiyama [Japon] ; Enzhi Yin [Japon, République populaire de Chine] ; Tadanori Harada [Japon] ; Ken Otsuka [Japon] ; Shigefumi Matsuyama [Japon] ; Tomohiro Imazuru [Japon] ; Tomoki Shimokawa [Japon] ; Masanori Niimi [Japon]Source :
- Evidence-based Complementary and Alternative Medicine : eCAM [ 1741-427X ] ; 2014.
Abstract
In previous studies, we have demonstrated that Tokishakuyakusan (TJ-23) can prolong the survival of allogeneic cardiac grafts and induce regulatory T cells. In this study we investigated the effects of Paeoniae radix and Cnidii rhizoma, two components of TJ-23, on alloimmune responses in a murine cardiac transplantation model and whether the two agents have synergistic effect. CBA mice underwent transplantation of a C57BL/6 heart and received oral administration of 2 g/kg/day of Paeoniae radix, Cnidii rhizoma, or the mixture of two agents from the day of transplantation until 7 days afterward. Naïve CBA mice rejected C57BL/6 cardiac graft acutely (median survival time (MST): 7 days). Paeoniae radix and Cnidii rhizoma prolonged C57BL/6 allograft survival (MSTs: 13.5 and 15.5 days, resp.). However, the mixture of two agents prolonged C57BL/6 allograft survival indefinitely (MST > 100 days). Secondary CBA recipients given whole splenocytes from primary combination-treated CBA recipients with B6 cardiac allografts 30 days after grafting had prolonged survival of B6 hearts (MST: 33 days). Flow cytometry studies showed that the CD4+CD25+Foxp3+ regulatory cell population was increased in combination-treated recipients. Combination of Paeoniae radix and Cnidii rhizoma induced hyporesponsiveness to fully allogeneic cardiac allografts and may generate CD4+CD25+Foxp3+ regulatory cells in our model.
Url:
DOI: 10.1155/2014/841408
PubMed: 24772184
PubMed Central: 3977559
Affiliations:
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sortKey="Imazuru, Tomohiro" sort="Imazuru, Tomohiro" uniqKey="Imazuru T" first="Tomohiro" last="Imazuru">Tomohiro Imazuru</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Cardiovascular Surgery, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Cardiovascular Surgery, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Shimokawa, Tomoki" sort="Shimokawa, Tomoki" uniqKey="Shimokawa T" first="Tomoki" last="Shimokawa">Tomoki Shimokawa</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Cardiovascular Surgery, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Cardiovascular Surgery, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 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Kaga, Itabashi-ku, Tokyo 173-8605, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Department of Cardiovascular and Thoracic Surgery, the 4th Affiliated Hospital of Harbin Medical University, 37 Yiyuan Street, Nangang, Harbin, Heilongjiang 150001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Cardiovascular and Thoracic Surgery, the 4th Affiliated Hospital of Harbin Medical University, 37 Yiyuan Street, Nangang, Harbin, Heilongjiang 150001</wicri:regionArea><wicri:noRegion>Heilongjiang 150001</wicri:noRegion></affiliation></author><author><name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Surgery, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="I3">Department of General Surgery, the 2nd Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang, Harbin, Heilongjiang 150086, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of General Surgery, the 2nd Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang, Harbin, Heilongjiang 150086</wicri:regionArea><wicri:noRegion>Heilongjiang 150086</wicri:noRegion></affiliation></author><author><name sortKey="Uchiyama, Masateru" sort="Uchiyama, Masateru" uniqKey="Uchiyama M" first="Masateru" last="Uchiyama">Masateru Uchiyama</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Surgery, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="I4">Department of Cardiovascular Surgery, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Cardiovascular Surgery, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Yin, Enzhi" sort="Yin, Enzhi" uniqKey="Yin E" first="Enzhi" last="Yin">Enzhi Yin</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Surgery, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="I5">Department of Cardiovascular Surgery, the 2nd Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang, Harbin, Heilongjiang 150086, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Cardiovascular Surgery, the 2nd Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang, Harbin, Heilongjiang 150086</wicri:regionArea><wicri:noRegion>Heilongjiang 150086</wicri:noRegion></affiliation></author><author><name sortKey="Harada, Tadanori" sort="Harada, Tadanori" uniqKey="Harada T" first="Tadanori" last="Harada">Tadanori Harada</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Cardiovascular Surgery, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Cardiovascular Surgery, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Otsuka, Ken" sort="Otsuka, Ken" uniqKey="Otsuka K" first="Ken" last="Otsuka">Ken Otsuka</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Cardiovascular Surgery, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Cardiovascular Surgery, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Matsuyama, Shigefumi" sort="Matsuyama, Shigefumi" uniqKey="Matsuyama S" first="Shigefumi" last="Matsuyama">Shigefumi Matsuyama</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Cardiovascular Surgery, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Cardiovascular Surgery, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Imazuru, Tomohiro" sort="Imazuru, Tomohiro" uniqKey="Imazuru T" first="Tomohiro" last="Imazuru">Tomohiro Imazuru</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Cardiovascular Surgery, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Cardiovascular Surgery, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Shimokawa, Tomoki" sort="Shimokawa, Tomoki" uniqKey="Shimokawa T" first="Tomoki" last="Shimokawa">Tomoki Shimokawa</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Cardiovascular Surgery, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Cardiovascular Surgery, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Niimi, Masanori" sort="Niimi, Masanori" uniqKey="Niimi M" first="Masanori" last="Niimi">Masanori Niimi</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Surgery, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author></analytic><series><title level="j">Evidence-based Complementary and Alternative Medicine : eCAM</title><idno type="ISSN">1741-427X</idno><idno type="e-ISSN">1741-4288</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In previous studies, we have demonstrated that Tokishakuyakusan (TJ-23) can prolong the survival of allogeneic cardiac grafts and induce regulatory T cells. In this study we investigated the effects of Paeoniae radix and Cnidii rhizoma, two components of TJ-23, on alloimmune responses in a murine cardiac transplantation model and whether the two agents have synergistic effect. CBA mice underwent transplantation of a C57BL/6 heart and received oral administration of 2 g/kg/day of Paeoniae radix, Cnidii rhizoma, or the mixture of two agents from the day of transplantation until 7 days afterward. Naïve CBA mice rejected C57BL/6 cardiac graft acutely (median survival time (MST): 7 days). Paeoniae radix and Cnidii rhizoma prolonged C57BL/6 allograft survival (MSTs: 13.5 and 15.5 days, resp.). However, the mixture of two agents prolonged C57BL/6 allograft survival indefinitely (MST > 100 days). Secondary CBA recipients given whole splenocytes from primary combination-treated CBA recipients with B6 cardiac allografts 30 days after grafting had prolonged survival of B6 hearts (MST: 33 days). Flow cytometry studies showed that the CD4<sup>+</sup>CD25<sup>+</sup>Foxp3<sup>+</sup> regulatory cell population was increased in combination-treated recipients. Combination of Paeoniae radix and Cnidii rhizoma induced hyporesponsiveness to fully allogeneic cardiac allografts and may generate CD4<sup>+</sup>CD25<sup>+</sup>Foxp3<sup>+</sup> regulatory cells in our model.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q Zhang</name></author><author><name sortKey="Uchiyama, M" uniqKey="Uchiyama M">M Uchiyama</name></author><author><name sortKey="Jin, X" uniqKey="Jin X">X Jin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q Zhang</name></author><author><name sortKey="Iwami, D" uniqKey="Iwami D">D Iwami</name></author><author><name sortKey="Aramaki, O" uniqKey="Aramaki O">O Aramaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jin, X" uniqKey="Jin X">X Jin</name></author><author><name sortKey="Uchiyama, M" uniqKey="Uchiyama M">M Uchiyama</name></author><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q Zhang</name></author><author><name sortKey="Watanabe, T" uniqKey="Watanabe T">T Watanabe</name></author><author><name sortKey="Niimi, M" uniqKey="Niimi M">M Niimi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Niimi, M" uniqKey="Niimi M">M Niimi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Kk" uniqKey="Lee K">KK Lee</name></author><author><name sortKey="Omiya, Y" uniqKey="Omiya Y">Y Omiya</name></author><author><name sortKey="Yuzurihara, M" uniqKey="Yuzurihara M">M Yuzurihara</name></author><author><name sortKey="Kase, Y" uniqKey="Kase Y">Y Kase</name></author><author><name sortKey="Kobayashi, H" uniqKey="Kobayashi H">H Kobayashi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Uchiyama, M" uniqKey="Uchiyama M">M Uchiyama</name></author><author><name sortKey="Jin, X" uniqKey="Jin X">X 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Mezrich</name></author><author><name sortKey="Yamada, K" uniqKey="Yamada K">K Yamada</name></author><author><name sortKey="Sachs, Dh" uniqKey="Sachs D">DH Sachs</name></author><author><name sortKey="Madsen, Jc" uniqKey="Madsen J">JC Madsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="King, Cl" uniqKey="King C">CL King</name></author><author><name sortKey="Devitt, Jj" uniqKey="Devitt J">JJ Devitt</name></author><author><name sortKey="Lee, Tdg" uniqKey="Lee T">TDG Lee</name></author><author><name sortKey="Hancock Friesen, Cl" uniqKey="Hancock Friesen C">CL Hancock Friesen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Atluri, P" uniqKey="Atluri P">P Atluri</name></author><author><name sortKey="Hiesinger, W" uniqKey="Hiesinger W">W Hiesinger</name></author><author><name sortKey="Gorman, Rc" uniqKey="Gorman R">RC Gorman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Devitt, Jj" uniqKey="Devitt J">JJ Devitt</name></author><author><name sortKey="King, Cl" uniqKey="King C">CL King</name></author><author><name sortKey="Lee, Tdg" uniqKey="Lee T">TDG Lee</name></author><author><name sortKey="Hancock Friesen, Cl" uniqKey="Hancock Friesen C">CL Hancock Friesen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name></author><author><name sortKey="Lamb, Jr" uniqKey="Lamb J">JR Lamb</name></author><author><name sortKey="Tam, Pkh" uniqKey="Tam P">PKH Tam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Uchiyama, M" uniqKey="Uchiyama M">M Uchiyama</name></author><author><name sortKey="Jin, X" uniqKey="Jin X">X Jin</name></author><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, Y" uniqKey="Sun Y">Y Sun</name></author><author><name sortKey="Cai, T T" uniqKey="Cai T">T-T Cai</name></author><author><name sortKey="Shen, Y" uniqKey="Shen Y">Y Shen</name></author><author><name sortKey="Zhou, X B" uniqKey="Zhou X">X-B Zhou</name></author><author><name sortKey="Chen, T" uniqKey="Chen T">T Chen</name></author><author><name sortKey="Xu, Q" uniqKey="Xu Q">Q Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Watanabe, T" uniqKey="Watanabe T">T Watanabe</name></author><author><name sortKey="Yamamoto, T" uniqKey="Yamamoto T">T Yamamoto</name></author><author><name sortKey="Yoshida, M" uniqKey="Yoshida M">M Yoshida</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamamoto, T" uniqKey="Yamamoto T">T Yamamoto</name></author><author><name sortKey="Fujiwara, K" uniqKey="Fujiwara K">K Fujiwara</name></author><author><name sortKey="Yoshida, M" uniqKey="Yoshida M">M Yoshida</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Yang, Clh" uniqKey="Yang C">CLH Yang</name></author><author><name sortKey="Or, Tct" uniqKey="Or T">TCT Or</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Japon</li><li>République populaire de Chine</li></country><settlement><li>Tokyo</li></settlement></list><tree><country name="Japon"><noRegion><name sortKey="Jin, Xiangyuan" sort="Jin, Xiangyuan" uniqKey="Jin X" first="Xiangyuan" last="Jin">Xiangyuan Jin</name></noRegion><name sortKey="Harada, Tadanori" sort="Harada, Tadanori" uniqKey="Harada T" first="Tadanori" last="Harada">Tadanori Harada</name><name sortKey="Imazuru, Tomohiro" sort="Imazuru, Tomohiro" uniqKey="Imazuru T" first="Tomohiro" last="Imazuru">Tomohiro Imazuru</name><name sortKey="Matsuyama, Shigefumi" sort="Matsuyama, Shigefumi" uniqKey="Matsuyama S" first="Shigefumi" last="Matsuyama">Shigefumi Matsuyama</name><name sortKey="Niimi, Masanori" sort="Niimi, Masanori" uniqKey="Niimi M" first="Masanori" last="Niimi">Masanori Niimi</name><name sortKey="Otsuka, Ken" sort="Otsuka, Ken" uniqKey="Otsuka K" first="Ken" last="Otsuka">Ken Otsuka</name><name sortKey="Shimokawa, Tomoki" sort="Shimokawa, Tomoki" uniqKey="Shimokawa T" first="Tomoki" last="Shimokawa">Tomoki Shimokawa</name><name sortKey="Uchiyama, Masateru" sort="Uchiyama, Masateru" uniqKey="Uchiyama M" first="Masateru" last="Uchiyama">Masateru Uchiyama</name><name sortKey="Uchiyama, Masateru" sort="Uchiyama, Masateru" uniqKey="Uchiyama M" first="Masateru" last="Uchiyama">Masateru Uchiyama</name><name sortKey="Yin, Enzhi" sort="Yin, Enzhi" uniqKey="Yin E" first="Enzhi" last="Yin">Enzhi Yin</name><name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Jin, Xiangyuan" sort="Jin, Xiangyuan" uniqKey="Jin X" first="Xiangyuan" last="Jin">Xiangyuan Jin</name></noRegion><name sortKey="Yin, Enzhi" sort="Yin, Enzhi" uniqKey="Yin E" first="Enzhi" last="Yin">Enzhi Yin</name><name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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